Cooperstown is located in the Central Leatherstocking Region of Central New York. It is 70 miles west of Albany, 30 miles south of the New York State Thruway, and 16 miles north of Oneonta.

From New York City:

• Scenic Route:
  
  - Follow the NYS Thruway North to Exit 21
  - Follow Route 23 West into Oneonta
  - Follow I-88/State Route 28 East toward Albany
  - Take Exit 17 and Follow State Rt. 28 North
     (16 miles to Cooperstown)

• Via Toll Road:
  - Follow the New York State Thruway (I-90) to Exit 30 (Herkimer)
  - Take State Route 28 South to Cooperstown
   

• To Avoid most of the Toll and the Hill:
  
  - In Syracuse, follow I-81 South to Route 20 East
  - (or)  In Utica, follow Route 8 South to Route 20 East
  - In Richfield Springs, Follow State Route 28 south to Cooperstown

• Albany, NY:  1½ hours

• Binghamton, NY: 1½ hours

• Boston, MA:   4½ hours

• Cleveland, OH:  8 hours

• New York City: 4-5½ hours

• Niagara Falls: 5 hours

• Syracuse: 2½ hours